MYCNOSfunctions as an antisense RNA regulatingMYCN
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چکیده
منابع مشابه
tcRNA as a naturally occurring antisense RNA in eukaryotes.
Since the formulation of our or ig ina l hypothesis that small RNAs are involved with gene expression by the i r associat ion with mRNAs (1) numerous reports have appeared demonstrating the i r role in processing and t r ansc r ip t ion termination (2,3) as well as regulation of t rans la t ion (4 ,5 ) . In the l a t t e r case i t has been shown in E. co l i t ha t antisense RNAs (complementar...
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We have developed a novel class of antisense agents, RNA Lassos, which are capable of binding to and circularizing around complementary target RNAs. The RNA Lasso consists of a fixed sequence derived from the hairpin ribozyme and an antisense segment whose size and sequence can be varied to base pair with accessible sites in the target RNA. The ribozyme catalyzes self-processing of the 5'- and ...
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For a long time, RNA has been merely regarded as a molecule that can either function as a messenger (mRNA) or as part of the translational machinery (tRNA, rRNA). Meanwhile, it became clear that RNAs are versatile molecules that do not only play key roles in many important biological processes like splicing, editing, protein export and others, but can also--like enzymes--act catalytically. Two ...
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I am sorry to say that the evaluation of your manuscript is not a positive one. As you will see, while the referees acknowledge that the findings are potentially very interesting, they also point out that the data are insufficient to support the proposed model. All referees note that the biological relevance of the role of AS-RBM15 in RBM15 translation and megakaryocytic differentiation remains...
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Myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia, are clonal diseases arising in hematopoietic stem or progenitor cells. In recent years, microRNA (miRNA) expression profiling studies have revealed close associations of miRNAs with cytogenetic and molecular subtypes of myeloid malignancies, as well as outcome and prognosis of patients. However, the roles of m...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2015
ISSN: 1547-6286,1555-8584
DOI: 10.1080/15476286.2015.1063773